Water → 7-[(2-Hydroxy-1,1-dimethylethyl)amino]-5-[(phenylmethyl)thio]thiazolo[4,5-d]pyrimidin-2(3H)-one

HRID 1097327노트

반응식

HRID 1097327 반응식
C[O:2][C:3]1[S:4][C:5]2[C:10]([NH:11][C:12]([CH3:16])([CH3:15])[CH2:13][OH:14])=[N:9][C:8]([S:17][CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[N:7][C:6]=2[N:25]=1.O>O1CCOCC1.Cl>[OH:14][CH2:13][C:12]([NH:11][C:10]1[C:5]2[S:4][C:3](=[O:2])[NH:25][C:6]=2[N:7]=[C:8]([S:17][CH2:18][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[N:9]=1)([CH3:15])[CH3:16]

참가 물질

5

반응물 2

HCID 962WaterHCID 226712732-[[2-Methoxy-5-[(phenylmethyl)thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-2-methyl-1-propanol

생성물 1

HCID 99289397-[(2-Hydroxy-1,1-dimethylethyl)amino]-5-[(phenylmethyl)thio]thiazolo[4,5-d]pyrimidin-2(3H)-one

시약·촉매·용매 2

HCID 313Hydrochloric Acid촉매HCID 312751,4-Dioxane용매

반응 조건

온도
45 °C

실험 절차

To a solution of the product from example 1 step f) (0.21 g) in 1,4-dioxane (5 ml) was added water (0.1 ml) and concentrated hydrochloric acid (1 drop). The mixture heated at 45° C. for 3 hours then evaporated to dryness. Recrystallisation (acetonitrile) gave the title compound (0.110 g).

후처리

  1. customthen evaporated to dryness
  2. customRecrystallisation (acetonitrile)

출처 및 근거

ORD 기록
ord-b5a247cc7aaf47408635da9d11ecd6f7
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08143261B2

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