Hydrochloric Acid → 5-[[(2-fluorophenyl)methyl]thio]-7-[[(1R)-2-hydroxy-1-methylethyl]amino]thiazolo[4,5-d]pyrimidin-2(3H)-one

HRID 1097368노트

반응식

HRID 1097368 반응식
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][S:9][C:10]1[N:11]=[C:12]([NH:21][C@H:22]([CH3:25])[CH2:23][OH:24])[C:13]2[S:18][C:17]([O:19]C)=[N:16][C:14]=2[N:15]=1.O.Cl>O1CCOCC1>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][S:9][C:10]1[N:11]=[C:12]([NH:21][C@H:22]([CH3:25])[CH2:23][OH:24])[C:13]2[S:18][C:17](=[O:19])[NH:16][C:14]=2[N:15]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 235198412-[[5-[[(2-fluorophenyl)methyl]thio]-2-methoxythiazolo[4,5-d]pyrimidin-7-yl]amino]-(2R)-1-propanol

생성물 1

HCID 235198525-[[(2-fluorophenyl)methyl]thio]-7-[[(1R)-2-hydroxy-1-methylethyl]amino]thiazolo[4,5-d]pyrimidin-2(3H)-one

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

The product of example 32 step e) was dissolved in 1,4-dioxane (50 ml), H2O (1 ml) and concentrated HCl solution (0.5 ml) and stirred for 20 h at 40° C. The volatiles were removed under reduced-pressure and the crude product purified by preparative HPLC to afford the subtitle compound as a white solid (21 mg).

후처리

  1. customThe volatiles were removed under reduced-pressure
  2. customthe crude product purified by preparative HPLC

출처 및 근거

ORD 기록
ord-b89cc663241a4bbdbdf52d6708847032
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08143261B2

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