Sodium borohydride → HCID 59277703, 화합물

HRID 1097775노트

반응식

HRID 1097775 반응식
[BH4-].[Na+].[CH3:3][N:4]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[C:7](=[O:14])[C:6]([CH3:16])([CH3:15])[S:5]1(=[O:18])=[O:17]>CCO>[CH3:3][N:4]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[CH:7]([OH:14])[C:6]([CH3:16])([CH3:15])[S:5]1(=[O:17])=[O:18]

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 59277705HCID 59277705, 화합물

생성물 1

HCID 59277703HCID 59277703, 화합물수율 100%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

NaBH4 (45 mg, 1.2 mmol) is added to a solution of 1,3,3-Trimethyl-2,2-dioxo-2,3-dihydro-1H-benzo[c][1,2]thiazin-4-one (190 mg, 0.8 mmol) in 15 mL of EtOH at 0° C. The resulting mixture is stirred at this temperature for overnight. The reaction is quenched by HCl (1M), and extracted with ethyl acetate (15 mL×3). The combined extracts are dried over anhydrous Na2SO4. After filtration and concentration, the residue is purified by flash column and yields the title compound as oil (193 mg).

후처리

  1. customThe reaction is quenched by HCl (1M)
  2. extractionextracted with ethyl acetate (15 mL×3)
  3. dry with materialThe combined extracts are dried over anhydrous Na2SO4
  4. filtrationAfter filtration and concentration
  5. customthe residue is purified by flash column

출처 및 근거

ORD 기록
ord-20043f9432974a28b0460af2f9fb8491
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08143278B2

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