Acetic Anhydride → 1,1-Cyclohexanediacetic Anhydride

HRID 1099480노트

반응식

HRID 1099480 반응식
[C:1]1([CH2:11][C:12]([OH:14])=[O:13])([CH2:7][C:8]([OH:10])=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(OC(=O)C)(=O)C>>[C:1]12([CH2:7][C:8](=[O:10])[O:14][C:12](=[O:13])[CH2:11]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]2

참가 물질

3

반응물 2

HCID 7918Acetic AnhydrideHCID 78061Cyclohexanediacetic acid

생성물 1

HCID 27342891,1-Cyclohexanediacetic Anhydride수율 100%

실험 절차

A suspension of 1,1-cyclohexanediacetic acid (39.95 mmol) in acetic anhydride (159.8 mmol) was refluxed gently until a clear solution was obtained (ca. 1 h). The reaction mixture was kept at reflux for another hour until the reaction was complete. The reaction mixture was cooled to room temperature and acetic acid and excess acetic anhydride were removed under vacuum to afford 7.28 g (100%) of (3). 1H NMR (CDCl3): 2.65 (4H, s); 1.54-1.43 (10H, m).

후처리

  1. temperaturewas refluxed gently until a clear solution
  2. customwas obtained (ca. 1 h)
  3. temperatureat reflux for another hour until the reaction
  4. customacetic acid and excess acetic anhydride were removed under vacuum

출처 및 근거

ORD 기록
ord-51de30396c24492eb2e411b3fe2b9630
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08143437B2

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