Maleimide → tetrahydropyrrolo[3,4-c]carbazole-1,3(2H, 3aH)-dione

HRID 11040

반응식

ClC1C=CC=CC=1[CH:8]=[CH:9][C:10]1[N:11](CCO)[C:12]2[C:17]([CH:18]=1)=[CH:16][C:15](OC)=[CH:14][CH:13]=2.[C:24]1(=[O:30])[NH:28][C:27](=[O:29])[CH:26]=[CH:25]1>>[C:24]1(=[O:30])[C:25]2[CH:26]([CH2:8][CH2:9][CH:10]3[C:18]=2[C:17]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[NH:11]3)[C:27](=[O:29])[NH:28]1

참가 물질

반응물 2

HCID 10935Maleimide

HCID 738577322-{2-[2-(2-Chlorophenyl)ethenyl]-5-methoxy-1H-indol-1-yl}ethanol2회

생성물 1

HCID 131725903tetrahydropyrrolo[3,4-c]carbazole-1,3(2H, 3aH)-dione수율 79%

실험 절차

Reaction of 2-{2-[2-(2-Chlorophenyl)ethenyl]-5-methoxy-1H-indol-1-yl}ethanol (III; Ar=2-chlorophenyl, R10═CH2CH2OH) (44) prepared according to example 41 with maleimide according to the procedure described in example 68 gave 4-(2-Chlorophenyl)-6-(2-hydroxyethyl)-9-methoxy-4,5,6,1 Oc-tetrahydropyrrolo[3,4-c]carbazole-1,3(2H, 3aH)-dione (IV; Ar=2-chlorophenyl, R10═CH2CH2OH) (45) in a 79% yield as an oily solid, which was used without further purification.

출처 및 근거

ORD 기록: ord-7c0e1b6db3f34a84be1395fb66bcc132
출처 데이터셋: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07094798B1

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