Ethylene Glycol → 2-Hydroxyethyl N-methyl-N-phenylglycinate

HRID 1105776

반응식

HRID 1105776 반응식
[CH2:1]([OH:4])[CH2:2][OH:3].[CH3:5][N:6]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:7][C:8](OCC)=[O:9].C[O-].[Na+].Cl>O>[CH3:5][N:6]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:7][C:8]([O:3][CH2:2][CH2:1][OH:4])=[O:9]

참가 물질

6

반응물 4

HCID 174Ethylene GlycolHCID 313Hydrochloric AcidHCID 265936(Methyl-phenyl-amino)-acetic acid ethyl esterHCID 10942334Sodium Methoxide

생성물 1

HCID 205549612-Hydroxyethyl N-methyl-N-phenylglycinate

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
150 °C

실험 절차

Into a 100 ml. flask fitted with a condenser and a Dean-Stark trap there were placed 49.5 gms. ethylene glycol, 17 gms. of ethyl N-methyl-N-phenylglycinate and 0.7 gm. sodium methoxide. The flask and contents were heated to 150° C. in an oil bath and stirred for 13 hours. The reaction mixture was allowed to cool to room temperature and 1.25 ml. of concentrated HCl in 3.5 ml. water were added and the mixture was stirred for 10 minutes. After the ethylene glycol was distilled off at atmospheric pressure, 11.5 gms. of product was obtained by vacuum distillation, b.p. (0.3 mm.) 139°-149° C.

후처리

  1. customflask fitted with a condenser
  2. temperatureto cool to room temperature
  3. stirringthe mixture was stirred for 10 minutes
  4. distillationAfter the ethylene glycol was distilled off at atmospheric pressure, 11.5 gms
  5. customof product was obtained by vacuum distillation, b.p
  6. custom(0.3 mm.) 139°-149° C.

출처 및 근거

ORD 기록
ord-a42ba69b9911477aacbdbc293192e764
출처 데이터셋
uspto-grants-1982_01
특허 번호
US04310512

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