Benzoyl chloride → HCID 13023186, 화합물

HRID 1105837노트

반응식

HRID 1105837 반응식
[C:1]([NH:5][C:6](=[S:23])[NH:7][C:8]1[CH:9]=[C:10]([CH:19]=[CH:20][C:21]=1[NH2:22])[C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:12])([O:3][CH3:4])=[O:2].[C:24](Cl)(=[O:31])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>C1(C)C=CC=CC=1>[C:1]([NH:5][C:6](=[S:23])[NH:7][C:8]1[CH:9]=[C:10]([CH:19]=[CH:20][C:21]=1[NH:22][C:24](=[O:31])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:12])([O:3][CH3:4])=[O:2]

참가 물질

4

반응물 2

HCID 7412Benzoyl chlorideHCID 30369724-Amino-3-(3'-methoxycarbonyl-2'-thioureido)benzophenone

생성물 1

HCID 13023186HCID 13023186, 화합물수율 65%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a suspension of 3-(3-carbomethoxythioureido)-4-aminobenzophenone (3.29 g.) in toluene (200 ml.) is added benzoyl chloride (1.4 g.). The mixture is refluxed for 18 hours, cooled to room temperature and the precipitate collected, washed with hexane and dried to afford 2.8 g. (65% yield) of 3-(3-carbomethoxythioureido)-4-benzamidobenzophenone as a gray solid, m.p. 191°-192° C., dec.

후처리

  1. temperatureThe mixture is refluxed for 18 hours
  2. customthe precipitate collected
  3. washwashed with hexane
  4. customdried
  5. customto afford 2.8 g

출처 및 근거

ORD 기록
ord-1aac0dfee42d4aa389293573138ab584
출처 데이터셋
uspto-grants-1982_01
특허 번호
US04310537

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