Sodium Iodide → 5-(N,N-Dimethylthiocarbamoyl)thio-4-methyl-2-phenyl-4-isothiazolin-3-one

HRID 1105880

반응식

HRID 1105880 반응식
Cl[C:2]1[S:6][N:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:4](=[O:13])[C:3]=1[CH3:14].[CH3:15][N:16]([CH3:20])[C:17](=[S:19])[SH:18].[Na].[I-].[Na+]>C(O)C>[CH3:15][N:16]([CH3:20])[C:17]([S:19][C:2]1[S:6][N:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:4](=[O:13])[C:3]=1[CH3:14])=[S:18]

참가 물질

6

반응물 4

HCID 5238Sodium IodideHCID 6599Dimethyldithiocarbamic acidHCID 5360545SodiumHCID 198761675-chloro-4-methyl-2-phenylisothiazol-3(2H)-one

생성물 1

HCID 128527285-(N,N-Dimethylthiocarbamoyl)thio-4-methyl-2-phenyl-4-isothiazolin-3-one

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

To a solution of 4.51 g. (0.02 mole) of 5-chloro-4-methyl-2-phenyl-4-isothiazolin-3-one in 30 ml of warm ethanol was added a solution of 3.58 g. (0.02 mole) of N,N-dimethyldithiocarbamic acid, sodium salt dihydrate in 20 ml of ethanol followed by 0.1 g. of sodium iodide. The mixture was stirred several hours, cooled and filtered. The solid was triturated with water and dried to give 5.3 g. (88%) of the named product, mp 158°-160°.

후처리

  1. temperaturecooled
  2. filtrationfiltered
  3. customThe solid was triturated with water
  4. customdried
  5. customto give 5.3 g

출처 및 근거

ORD 기록
ord-14fd87cf8fe5449984c02e859ec68e5d
출처 데이터셋
uspto-grants-1982_01
특허 번호
US04310590

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