Hydrochloric Acid → 2-Hydroxynonanedioic acid

HRID 1105984노트

반응식

HRID 1105984 반응식
Br[CH:2]([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([O:15]C)=[O:14])[C:3]([O:5]C)=[O:4].C(=O)([O-])[O-:18].[Na+].[Na+].Cl.[Cl-].[Na+]>O>[OH:18][CH:2]([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14])[C:3]([OH:5])=[O:4]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 5234Sodium ChlorideHCID 10340Sodium CarbonateHCID 12760707Dimethyl 2-bromononanedioate

생성물 1

HCID 127607082-Hydroxynonanedioic acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A stirred mixture of 295 g. of dimethyl 2-bromononanedioate, [Acta. Chim. Acad. Sci. Hung., 46, 85 (1965)], 371 g. of anhydrous sodium carbonate, and 3 liters of water is heated at reflux for 22 hours. The solution which forms is cooled and acidified with 600 ml. of 12 N hydrochloric acid. The mixture is saturated with sodium chloride and extracted with ethyl acetate. The extract is washed with brine, dried over magnesium sulfate, and concentrated to give 184 g. of white solid, m.p. 86°-92° C.

후처리

  1. additionA stirred mixture of 295 g
  2. temperatureat reflux for 22 hours
  3. temperatureThe solution which forms is cooled
  4. extractionextracted with ethyl acetate
  5. washThe extract is washed with brine
  6. dry with materialdried over magnesium sulfate
  7. concentrationconcentrated
  8. customto give 184 g

출처 및 근거

ORD 기록
ord-e77df4e1068c4bb58f17c826db39247d
출처 데이터셋
uspto-grants-1982_01
특허 번호
US04310700

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