Isobutyraldehyde → 3-Ethyl-2-(propan-2-yl)-1,3-oxazolidine

HRID 1106128노트

반응식

HRID 1106128 반응식
[CH:1](=[O:5])[CH:2]([CH3:4])[CH3:3].[CH2:6]([NH:8][CH2:9][CH2:10]O)[CH3:7]>C1C=CC=CC=1>[CH:2]([CH:1]1[N:8]([CH2:9][CH3:10])[CH2:6][CH2:7][O:5]1)([CH3:4])[CH3:3]

참가 물질

4

반응물 2

HCID 6561IsobutyraldehydeHCID 80722-(Ethylamino)ethanol

생성물 1

HCID 2588383-Ethyl-2-(propan-2-yl)-1,3-oxazolidine

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

Iso-butyraldehyde (11.1 g; 0.15 moles) was added slowly over a period of 1 hour to N-ethyl-2-hydroxyethylamine (13.3 g; 0.15 moles) at a temperature of 25°-30° C. Benzene (100 ml) was then added, and the resulting solution was heated to reflux. Continuous azeotropic distillation removed 2.8 ml of water. The benzene was then removed by vacuum distillation to give the desired 2-isopropyl-3-ethyl-1,3-oxazolidine as a yellow liquid.

후처리

  1. temperaturethe resulting solution was heated to reflux
  2. distillationContinuous azeotropic distillation
  3. customremoved 2.8 ml of water
  4. customThe benzene was then removed by vacuum distillation

출처 및 근거

ORD 기록
ord-9b4f380f3806411aab25c8692a8df7e9
출처 데이터셋
uspto-grants-1982_01
특허 번호
US04311827

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