P-Cresol → HCID 70530989, 화합물

HRID 1106355노트

반응식

HRID 1106355 반응식
[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][C@@H:9]([OH:12])[C@H:8]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:7]1)=[O:5])[CH3:2].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[CH:38]1[C:43](O)=[CH:42][CH:41]=[C:40]([CH3:45])[CH:39]=1.N(C(OCC)=O)=NC(OCC)=O>C1C=CC=CC=1>[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][C@H:9]([O:12][C:43]2[CH:42]=[CH:41][C:40]([CH3:45])=[CH:39][CH:38]=2)[C@H:8]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:7]1)=[O:5])[CH3:2]

참가 물질

6

반응물 4

HCID 2879P-CresolHCID 11776TriphenylphosphineHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 13039299HCID 13039299, 화합물

생성물 1

HCID 70530989HCID 70530989, 화합물

시약·촉매·용매 1

HCID 241Benzene용매2회

실험 절차

To a stirred mixture of 6.23 g of trans-1-ethoxycarbonyl-3-phenyl-4-piperidinol, 7.21 g of triphenylphosphine, 2.97 g of p-cresol and 250 ml of benzene is added dropwise, at 50° C. under nitrogen, a solution of 4.79 g of diethyl azodicarboxylate in 250 ml of benzene. After the addition is complete, the mixture is stirred overnight at room temperature. The reaction mixture is processed according to the procedure of Example 75 to give the product as a gum.

후처리

  1. additionis added dropwise, at 50° C. under nitrogen
  2. additionAfter the addition

출처 및 근거

ORD 기록
ord-e85c28bc4acf41aaa6c317dc641ba299
출처 데이터셋
uspto-grants-1982_01
특허 번호
US04312876

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