2,4,5-Trimethoxybenzoyl chloride → N-(2,4,5-Trimethoxybenzoyl)-2-bromopyrrole

HRID 1106446

반응식

HRID 1106446 반응식
[CH3:1][O:2][C:3]1[CH:11]=[C:10]([O:12][CH3:13])[C:9]([O:14][CH3:15])=[CH:8][C:4]=1[C:5](Cl)=[O:6].[Br:16][C:17]1[NH:18][CH:19]=[CH:20][CH:21]=1>>[CH3:1][O:2][C:3]1[CH:11]=[C:10]([O:12][CH3:13])[C:9]([O:14][CH3:15])=[CH:8][C:4]=1[C:5]([N:18]1[CH:19]=[CH:20][CH:21]=[C:17]1[Br:16])=[O:6]

참가 물질

3

반응물 2

HCID 27608092,4,5-Trimethoxybenzoyl chlorideHCID 122352682-Bromopyrrole

생성물 1

HCID 18788308N-(2,4,5-Trimethoxybenzoyl)-2-bromopyrrole수율 55.1%

실험 절차

Following the procedure for Example B, 2,4,5-trimethoxybenzoyl chloride (1.38 g, 6 mmol) and 2-bromopyrrole (4 mmol) gave 0.75 g of the title compound: mp 120-121° C.; 1H NMR (CDCl3) δ: 7.05-6.95 (2 H, m), 6.52 (1 H, s), 6.35 (1 H, dd, J=3.3, 1.8), 6.18 (1 H, t, J=3.5), 3.96 (3 H, s), 3.86 (3 H, s), 3.76 (3 H, s).

출처 및 근거

ORD 기록
ord-94d669171bd14385845297a4523e4dd4
출처 데이터셋
uspto-grants-2000_05
특허 번호
US06057315

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