Sodium Hydroxide → 5-Hydroxy-2-methoxypyridine

HRID 1106607

반응식

HRID 1106607 반응식
C([O:4][C:5]1[CH:6]=[CH:7][C:8]([O:11][CH3:12])=[N:9][CH:10]=1)(=O)C.[OH-].[Na+]>CO>[OH:4][C:5]1[CH:6]=[CH:7][C:8]([O:11][CH3:12])=[N:9][CH:10]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 224515665-Acetoxy-2-methoxypyridine

생성물 1

HCID 116223355-Hydroxy-2-methoxypyridine수율 53.4%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of the 5-acetoxy-2-methoxypyridine(600 mg, 3.59 mmol) in MeOH(10 mL) was added 1M aq. NaOH(10 mL, 10 mmol). After stirring at r.t. for 30 min, volatile solvent was removed in vacuo, acidified with HOAc and extracted with CHCl3(3 x). The combined CHCl3 extracts were washed with H2O, dried(anhydrous MgSO4) and evaporated to give the title compound as a brown oil(240 mg, solidified on standing).

후처리

  1. customvolatile solvent was removed in vacuo
  2. extractionextracted with CHCl3(3 x)
  3. washThe combined CHCl3 extracts were washed with H2O, dried(anhydrous MgSO4) and
  4. customevaporated

출처 및 근거

ORD 기록
ord-a0fc49c836644fa49a69eaac378a3d51
출처 데이터셋
uspto-grants-2000_05
특허 번호
US06057319

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