Hydrochloric Acid → 2-(4-Methyl-3-methanesulfonylaminophenoxy)-acetimidic acid ethyl ester hydrochloride

HRID 1106717노트

반응식

HRID 1106717 반응식
[C:1]([CH2:3][O:4][C:5]1[CH:6]=[CH:7][C:8]([CH3:16])=[C:9]([NH:11][S:12]([CH3:15])(=[O:14])=[O:13])[CH:10]=1)#[N:2].[ClH:17].[CH2:18]([OH:20])[CH3:19]>ClCCl>[ClH:17].[CH2:18]([O:20][C:1](=[NH:2])[CH2:3][O:4][C:5]1[CH:6]=[CH:7][C:8]([CH3:16])=[C:9]([NH:11][S:12]([CH3:15])(=[O:14])=[O:13])[CH:10]=1)[CH3:19]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 18789597N-(5-cyanomethoxy-2-methylphenyl)-methanesulfonamide

생성물 1

HCID 693516472-(4-Methyl-3-methanesulfonylaminophenoxy)-acetimidic acid ethyl ester hydrochloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

N-(5-Cyanomethoxy-2-methylphenyl)-methanesulfonamide (3.48 g) was dissolved in a mixture of 70 ml of dichloromethane and 3.5 ml of ethanol. The reaction mixture was cooled in an ice bath, saturated with hydrogen chloride gas (Matheson, Newark, Calif.), and slowly allowed to come to room temperature and kept there for 16 hours. The solvent was evaporated leaving 5.2 g of 2-(4-methyl-3-methanesulfonylaminophenoxy)-acetimidic acid ethyl ester hydrochloride. ##STR77##

후처리

  1. customto come to room temperature
  2. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-c4f77a55ac6245baaf763bafcae6900a
출처 데이터셋
uspto-grants-2000_05
특허 번호
US06057349

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