Succinic anhydride → (R/S)-1-(1-adamantyl)methyl-2-(2-carboxyethyl)carbonyl-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole

HRID 1106933

반응식

HRID 1106933 반응식
[C:1]12([CH2:11][CH:12]3[C:17]4[NH:18][C:19]5[C:24]([C:16]=4[CH2:15][CH2:14][NH:13]3)=[CH:23][CH:22]=[CH:21][CH:20]=5)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[C:25]1(=[O:31])[O:30][C:28](=[O:29])[CH2:27][CH2:26]1>O1CCOCC1>[C:1]12([CH2:11][CH:12]3[C:17]4[NH:18][C:19]5[C:24]([C:16]=4[CH2:15][CH2:14][N:13]3[C:25]([CH2:26][CH2:27][C:28]([OH:30])=[O:29])=[O:31])=[CH:23][CH:22]=[CH:21][CH:20]=5)[CH2:10][CH:5]3[CH2:4][CH:3]([CH2:9][CH:7]([CH2:6]3)[CH2:8]1)[CH2:2]2

참가 물질

4

반응물 2

HCID 7922Succinic anhydrideHCID 53933490(R/S)-1-(1-adamantyl)methyl-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole

생성물 1

HCID 53950661(R/S)-1-(1-adamantyl)methyl-2-(2-carboxyethyl)carbonyl-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A mixture of (R/S)-1-(1-adamantyl)methyl-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole (640 mg, 2.0 mmol) and succinic anhydride (250 mg, 2.5 mmol) was stirred in dioxan (5 ml) at room temperature for 17 hours. The white precipiate which had formed was isolated by filtration, washed with dioxan and dried. (640 mg, 76%).

후처리

  1. customThe white precipiate which had formed
  2. customwas isolated by filtration
  3. washwashed with dioxan
  4. customdried

출처 및 근거

ORD 기록
ord-0532127899f14e8aba970fd530a877ab
출처 데이터셋
uspto-grants-2000_05
특허 번호
US06057311

연결된 노트

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