Phenylacetonitrile → Phenyl(pyridin-3-yl)acetonitrile

HRID 1107431노트

반응식

HRID 1107431 반응식
Cl[C:2]1[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=1.[CH2:8]([C:15]#[N:16])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.CC(C)([O-])C.[K+]>CN(C=O)C>[C:9]1([CH:8]([C:2]2[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=2)[C:15]#[N:16])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

참가 물질

5

반응물 3

HCID 8794PhenylacetonitrileHCID 122873-ChloropyridineHCID 23665647Potassium tert-butoxide

생성물 1

HCID 270956Phenyl(pyridin-3-yl)acetonitrile

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

The compound was prepared substantially in accordance with the procedure in Example 12A, using 3-chloropyridine (9.5 ml, 100 mmol), benzyl cyanide (11.6 ml, 100 mmol) and potassium t-butoxide (22.4 g, 200 mmol) in 200 ml of DMF.

후처리

  1. customThe compound was prepared substantially in accordance with the procedure in Example 12A

출처 및 근거

ORD 기록
ord-812c456818834fe4a33fa148a127b9cc
출처 데이터셋
uspto-grants-2000_05
특허 번호
US06060484

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