Diethylenetriamine → 2,2,2-trifluoro-N-[2-[2-[(2,2,2-trifluoroacetyl)amino]ethylamino]ethyl]acetamide

HRID 1107678

반응식

HRID 1107678 반응식
C(O[C:4](=[O:9])[C:5]([F:8])([F:7])[F:6])C.[NH2:10][CH2:11][CH2:12][NH:13][CH2:14][CH2:15][NH2:16]>O1CCCC1>[F:6][C:5]([F:8])([F:7])[C:4]([NH:10][CH2:11][CH2:12][NH:13][CH2:14][CH2:15][NH:16][C:4](=[O:9])[C:5]([F:6])([F:7])[F:8])=[O:9]

참가 물질

4

반응물 2

HCID 8111DiethylenetriamineHCID 9794Ethyl trifluoroacetate

생성물 1

HCID 3887782,2,2-trifluoro-N-[2-[2-[(2,2,2-trifluoroacetyl)amino]ethylamino]ethyl]acetamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

113.3 g (790 mmol) of trifluoroacetic acid ethyl ester is added in drops to a solution consisting of 41.14 g (390 mmol) of 1,4,7-triazaheptane in 350 ml of tetrahydrofuran at 80° C. and under nitrogen. It is allowed to stir overnight at room temperature, concentrated by evaporation in a vacuum. The remaining oil is crystallized from hexane.

후처리

  1. concentrationconcentrated by evaporation in a vacuum
  2. customThe remaining oil is crystallized from hexane

출처 및 근거

ORD 기록
ord-08d9df4b6ff04d1a823791c00f3a2ac4
출처 데이터셋
uspto-grants-2000_05
특허 번호
US06063361

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