Formamide → Ethyl 4-methyloxazole-5-carboxylate

HRID 1107695

반응식

HRID 1107695 반응식
[CH2:1]([O:3][C:4](=[O:10])[CH:5](Cl)[C:6]([CH3:8])=O)[CH3:2].[CH:11]([NH2:13])=[O:12].C(=O)([O-])[O-].[K+].[K+]>>[CH2:1]([O:3][C:4]([C:5]1[O:12][CH:11]=[N:13][C:6]=1[CH3:8])=[O:10])[CH3:2]

참가 물질

4

반응물 3

HCID 713FormamideHCID 11430Potassium CarbonateHCID 11858Ethyl 2-chloroacetoacetate

생성물 1

HCID 88558Ethyl 4-methyloxazole-5-carboxylate수율 39.8%

반응 조건

온도
120 °C

실험 절차

To ethyl-2-chloroacetoacetate(5.6 g) was added formamide(4.6 g). The reaction mixture was stirred at 120° C. for 12 hours, cooled to 0° C. and aqueous potassium carbonate was added thereto. The mixture was extracted with benzene, dried with anhydrous magnesium sulfate, and concentrated in vacuo to obtain the target product(2.1 g).

후처리

  1. temperaturecooled to 0° C.
  2. extractionThe mixture was extracted with benzene
  3. dry with materialdried with anhydrous magnesium sulfate
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-5df6a61042a447b080cb08964bf943f0
출처 데이터셋
uspto-grants-2000_05
특허 번호
US06063778

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