Sodium Hydroxide → 1-Acetyl-3-(2-hydroxyethyl)-4,6-dimethylindoline

HRID 1107955노트

반응식

HRID 1107955 반응식
[C:1]([N:4]1[C:12]2[C:7](=[C:8]([CH3:14])[CH:9]=[C:10]([CH3:13])[CH:11]=2)[CH:6]([CH2:15][CH2:16][O:17]C(=O)C)[CH2:5]1)(=[O:3])[CH3:2].[OH-].[Na+]>C(Cl)(Cl)Cl.CO.O>[C:1]([N:4]1[C:12]2[C:7](=[C:8]([CH3:14])[CH:9]=[C:10]([CH3:13])[CH:11]=2)[CH:6]([CH2:15][CH2:16][OH:17])[CH2:5]1)(=[O:3])[CH3:2]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 222473471-Acetyl-3-(2-acetoxyethyl)-4,6-dimethylindoline

생성물 1

HCID 222473161-Acetyl-3-(2-hydroxyethyl)-4,6-dimethylindoline수율 70.8%

시약·촉매·용매 2

HCID 962Water용매HCID 21584188Chloroform methanol용매

실험 절차

1-Acetyl-3-(2-acetoxyethyl)-4,6-dimethylindoline (2.0 g) was dissolved in a mixture of CHCl3 /MeOH=1/1 (25 ml), and a solution of NaOH (1.5 g) in water (5 ml) was added, which was followed by stirring at room temperature for 1 hr. The solvent was evaporated under reduced pressure. CHCl3 (100 ml) was added, and the mixture was washed with water and dried over anhydrous sodium sulfate. CHCl3 was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: CHCl3 /MeOH=50/1-10/1) to give 1.2 g of 1-acetyl-3-(2-hydroxyethyl)-4,6-dimethylindoline.

후처리

  1. customThe solvent was evaporated under reduced pressure
  2. additionCHCl3 (100 ml) was added
  3. washthe mixture was washed with water
  4. dry with materialdried over anhydrous sodium sulfate
  5. customCHCl3 was evaporated under reduced pressure
  6. customThe residue was purified by silica gel column chromatography (eluent: CHCl3 /MeOH=50/1-10/1)

출처 및 근거

ORD 기록
ord-f1bb1c3f82d44a7bab3e1d893d7f0ea0
출처 데이터셋
uspto-grants-2000_05
특허 번호
US06063806

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