Ethanol → 3-[(3,5-Dimethylphenyl)amino]propanoic acid

HRID 1107972노트

반응식

HRID 1107972 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([CH:10]=[C:11]([CH3:13])[CH:12]=1)[NH:5][CH2:6]CC#N.[OH-:14].[Na+].[CH2:16]([OH:18])[CH3:17]>O>[CH3:1][C:2]1[CH:3]=[C:4]([CH:10]=[C:11]([CH3:13])[CH:12]=1)[NH:5][CH2:6][CH2:17][C:16]([OH:14])=[O:18]

참가 물질

5

반응물 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 2926323-[(3,5-Dimethylphenyl)amino]propanenitrile

생성물 1

HCID 24348423-[(3,5-Dimethylphenyl)amino]propanoic acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

β-(3,5-Dimethylanilino)propionitrile (4.5 g) was dissolved in ethanol (50 ml), and a solution of NaOH (5.1 g) in water (25 ml) was added, which was followed by refluxing for 4 hr. The solvent was evaporated under reduced pressure. 2N Hydrochloric acid was added to adjust the residue acidic, and the mixture was washed with chloroform (100 ml). The aqueous layer was concentrated to about 20 ml and allowed to stand. The precipitated crystals were collected by filtration and dried to give 4.0 g of β-(3,5-dimethylanilino)propionic acid.

후처리

  1. temperatureby refluxing for 4 hr
  2. customThe solvent was evaporated under reduced pressure
  3. addition2N Hydrochloric acid was added
  4. washthe mixture was washed with chloroform (100 ml)
  5. concentrationThe aqueous layer was concentrated to about 20 ml
  6. filtrationThe precipitated crystals were collected by filtration
  7. customdried

출처 및 근거

ORD 기록
ord-8619bf8f1da2414f91f1f6730bdebda4
출처 데이터셋
uspto-grants-2000_05
특허 번호
US06063806

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