Hydrochloric Acid → (6R,7R)-7-amino-3-formyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

HRID 1108007

반응식

HRID 1108007 반응식
Cl.[NH2:2][CH:3]1[C:15](=[O:16])[N:5]2[C:6]([C:12]([OH:14])=[O:13])=[C:7]([CH:10]=[O:11])[CH2:8][S:9][C@H:4]12.N1C=CC=CC=1>CO>[NH2:2][C@@H:3]1[C:15](=[O:16])[N:5]2[C@@H:4]1[S:9][CH2:8][C:7]([CH:10]=[O:11])=[C:6]2[C:12]([OH:14])=[O:13]

참가 물질

5

반응물 3

HCID 313Hydrochloric Acid2회HCID 1049PyridineHCID 872037627-Amino-3-formyl-3-cephem-4-carboxylic acid

생성물 1

HCID 15385898(6R,7R)-7-amino-3-formyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

2.64 g of the hydrochloride of 6-amino-1,4,5a,6-tetrahydro-3-hydroxy-1,7-dioxo-3H,7H-aceto[2,1-b]furo[3,4-d][1,3]thiazine (hydroxylactone of the hydrochloride of 7-amino-3-formyl-3-cephem-4-carboxylic acid) are dissolved in 50 ml of methanol. A solution of 0.78 g of pyridine in 10 ml of methanol is added dropwise to this solution whilst stirring and cooling with ice. The precipitated product is filtered off under nitrogen whilst excluding moisture, washed with a little methanol and dried over a drying agent in vacuo at room temperature. (6R-trans)-7-amino-3formyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid is thus obtained in the form of a light brown powder.

후처리

  1. temperaturecooling with ice
  2. filtrationThe precipitated product is filtered off under nitrogen
  3. washwashed with a little methanol
  4. customdried over a drying agent in vacuo at room temperature

출처 및 근거

ORD 기록
ord-cfb5c91cf8544f00a772d0a49d3d43f0
출처 데이터셋
uspto-grants-2000_05
특허 번호
US06063917

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