Hydrochloric Acid → HCID 18785143, 화합물

HRID 1108496노트

반응식

HRID 1108496 반응식
C(OC([N:8]1[C:12]2[C:13]([F:19])=[CH:14][C:15]([NH2:18])=[C:16]([CH3:17])[C:11]=2[N:10]=[CH:9]1)=O)(C)(C)C.[ClH:20]>>[ClH:20].[CH3:17][C:16]1[C:11]2[NH:10][CH:9]=[N:8][C:12]=2[C:13]([F:19])=[CH:14][C:15]=1[NH2:18]

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 18785142HCID 18785142, 화합물

생성물 1

HCID 18785143HCID 18785143, 화합물

실험 절차

1-tert-Butoxycarbonyl-4-methyl-5-amino-7-fluorobenzimidazole (1 g) (prepared as described in U.S. Pat. No. 5,478,858 issued to Cupps and Bogdan, Dec. 26, 1995, incorporated herein by reference) and 6N HCl (10 mL) are combined and heated to reflux while stirring. After completion of the t-BOC group deprotection, the reaction mixture is concentrated under reduced pressure and dried to furnish 4methyl-5-amino-7-fluorobenzimidazole hydrochloride.

후처리

  1. temperatureheated
  2. temperatureto reflux
  3. concentrationAfter completion of the t-BOC group deprotection, the reaction mixture is concentrated under reduced pressure
  4. customdried

출처 및 근거

ORD 기록
ord-25207606004a45c7b45f8040b0f4e281
출처 데이터셋
uspto-grants-2000_05
특허 번호
US06066740

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