Hydrochloric Acid → 5-(3,4-Dimethoxyphenyl)cyclohexane-1,3-dione

HRID 1108754노트

반응식

HRID 1108754 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11]2[CH2:16][C:15](=[O:17])[CH2:14][C:13](=[O:18])[CH:12]2C(OCC)=O)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].Cl>[OH-].[K+]>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11]2[CH2:16][C:15](=[O:17])[CH2:14][C:13](=[O:18])[CH2:12]2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 18784169HCID 18784169, 화합물

생성물 1

HCID 8541355-(3,4-Dimethoxyphenyl)cyclohexane-1,3-dione수율 90.7%

시약·촉매·용매 1

HCID 14797Potassium Hydroxide용매

반응 조건

온도
50 °C

실험 절차

10% Aqueous solution of potassium hydroxide (760 ml) was added to ethyl 2-(3,4-dimethoxyphenyl)-4,6-dioxocyclohexane carboxylate (122 g), and the mixture was refluxed for 3.5 hours. After cooling the reaction solution on ice, it was adjusted to pH1 with concentrated hydrochloric acid, and stirred at 50° C. for an hour. After allowing the reaction solution to cool, the deposited crystals were filtered by suction and washed with purified water and isopropyl ether to give 85.8 g of 5-(3,4-dimethoxyphenyl)cyclohexane-1,3-dione (90.5%).

후처리

  1. temperaturethe mixture was refluxed for 3.5 hours
  2. temperatureAfter cooling the reaction solution on ice, it
  3. temperatureto cool
  4. filtrationthe deposited crystals were filtered by suction
  5. washwashed with purified water and isopropyl ether

출처 및 근거

ORD 기록
ord-6b7deb2b253a4881818a6a1f4c9b9727
출처 데이터셋
uspto-grants-2000_05
특허 번호
US06069176

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