Ammonium Hydroxide → 2,2-Dimethylpentanamide

HRID 1109270

반응식

HRID 1109270 반응식
[CH3:1][C:2]([CH3:9])([CH2:6][CH2:7][CH3:8])[C:3](Cl)=[O:4].[OH-].[NH4+:11]>>[CH3:1][C:2]([CH3:9])([CH2:6][CH2:7][CH3:8])[C:3]([NH2:11])=[O:4]

참가 물질

3

반응물 2

HCID 14923Ammonium HydroxideHCID 5191712,2-Dimethylvaleroyl chloride

생성물 1

HCID 831802,2-Dimethylpentanamide수율 86%

반응 조건

온도
1 °C

실험 절차

Ammonium hydroxide (250 ml) was stirred and cooled to 1° C. and 2,2-dimethyl valeroyl chloride (49.7 g, 95%, 318 mmol) was added dropwise over 30 minutes. After stirring at room temperature for an additional 1/2 hour, the white solid product was recovered by filtration, washed with water and allowed to air dry to give 35.4 g (86%) of the desired amide, mp 94°-95° (lit. mp 95°-96° C.).

후처리

  1. filtrationthe white solid product was recovered by filtration
  2. washwashed with water
  3. customto air dry

출처 및 근거

ORD 기록
ord-3a9e20c6bbea417cae8668dd93d16f00
출처 데이터셋
uspto-grants-1994_06
특허 번호
US05319133

연결된 노트

불러오는 중…