Chloroacetone → 1,3-Di-cyclobutylmethyl-7-(2-oxopropyl)-xanthine

HRID 1109486노트

반응식

HRID 1109486 반응식
[CH:1]1([CH2:5][N:6]2[C:15](=[O:16])[C:14]3[NH:13][CH:12]=[N:11][C:10]=3[N:9]([CH2:17][CH:18]3[CH2:21][CH2:20][CH2:19]3)[C:7]2=[O:8])[CH2:4][CH2:3][CH2:2]1.Cl[CH2:23][C:24](=[O:26])[CH3:25]>>[CH:1]1([CH2:5][N:6]2[C:15](=[O:16])[C:14]3[N:13]([CH2:23][C:24](=[O:26])[CH3:25])[CH:12]=[N:11][C:10]=3[N:9]([CH2:17][CH:18]3[CH2:21][CH2:20][CH2:19]3)[C:7]2=[O:8])[CH2:4][CH2:3][CH2:2]1

참가 물질

3

반응물 2

HCID 6571ChloroacetoneHCID 231680111,3-Di-cyclobutylmethyl xanthine

생성물 1

HCID 190206561,3-Di-cyclobutylmethyl-7-(2-oxopropyl)-xanthine

실험 절차

1,3-Di-cyclobutylmethyl-7-(2-oxopropyl)-xanthine was prepared from 1,3-di-cyclobutylmethyl xanthine and chloroacetone using an analogous procedure to that described in Example 5. The title compound was isolated as a crystalline solid, m.p. 155° C.

출처 및 근거

ORD 기록
ord-8811555ce6cf45449294dc529e13489b
출처 데이터셋
uspto-grants-1994_06
특허 번호
US05321029

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