Hydrochloric Acid → N-propyl-10-[1-(1-pyrroli-dinyl)-2-propyl]-2-phenothiazinecarboxamide hydrochloride

HRID 1109529노트

반응식

HRID 1109529 반응식
[ClH:1].[CH2:2]([NH:5][C:6]([C:8]1[CH:21]=[CH:20][C:19]2[S:18][C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]([CH:22]([CH3:29])[CH2:23][N:24]3[CH2:28][CH2:27][CH2:26][CH2:25]3)[C:10]=2[CH:9]=1)=[O:7])[CH2:3][CH3:4]>C(OC(C)C)(C)C.C(OCC)(=O)C>[ClH:1].[CH2:2]([NH:5][C:6]([C:8]1[CH:21]=[CH:20][C:19]2[S:18][C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]([CH:22]([CH3:29])[CH2:23][N:24]3[CH2:28][CH2:27][CH2:26][CH2:25]3)[C:10]=2[CH:9]=1)=[O:7])[CH2:3][CH3:4]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 9800851N-propyl-10-[1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide

생성물 1

HCID 67827161N-propyl-10-[1-(1-pyrroli-dinyl)-2-propyl]-2-phenothiazinecarboxamide hydrochloride

시약·촉매·용매 2

HCID 7914Diisopropyl Ether용매HCID 8857Ethyl Acetate용매

반응 조건

온도
5 °C

실험 절차

A 3.3N solution (6.2 cc) of hydrochloric acid in isopropyl ether is added dropwise in the course of 5 minutes to a solution of N-propyl-10-[1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide, L series (7.2 g), in anhydrous ethyl acetate (80 cc). The product deposits on the walls and crystallizes on scratching. The suspension obtained is maintained for one hour at a temperature in the region of 5° C. The solid is drained, washed with anhydrous ethyl acetate (3×5 cc) and dried under reduced pressure (5 mm Hg; 0.7 kPa) at 40° C. to give N-propyl-10-[1-(1-pyrroli-dinyl)-2-propyl]-2-phenothiazinecarboxamide hydrochloride, L series (7.1 g), in the form of a white solid, m.p. 190° C.

후처리

  1. customThe product deposits on the walls and crystallizes
  2. customThe suspension obtained
  3. washwashed with anhydrous ethyl acetate (3×5 cc)
  4. customdried under reduced pressure (5 mm Hg; 0.7 kPa) at 40° C.

출처 및 근거

ORD 기록
ord-c8fc27434a5f462ab7877d4e60ab109e
출처 데이터셋
uspto-grants-1994_06
특허 번호
US05321026

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