Methyl iodide → HCID 19020542, 화합물

HRID 1109536노트

반응식

HRID 1109536 반응식
[CH3:1][CH:2]([CH3:30])[CH2:3][CH2:4][NH:5][C:6]([C:8]1[CH:21]=[CH:20][C:19]2[S:18][C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]([CH:22]([CH3:29])[CH2:23][N:24]3[CH2:28][CH2:27][CH2:26][CH2:25]3)[C:10]=2[CH:9]=1)=[O:7].[CH3:31][I:32]>CC(C)=O>[I-:32].[CH3:31][N+:24]1([CH2:23][CH:22]([N:11]2[C:10]3[CH:9]=[C:8]([C:6](=[O:7])[NH:5][CH2:4][CH2:3][CH:2]([CH3:30])[CH3:1])[CH:21]=[CH:20][C:19]=3[S:18][C:17]3[C:12]2=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH3:29])[CH2:28][CH2:27][CH2:26][CH2:25]1

참가 물질

4

반응물 2

HCID 6328Methyl iodideHCID 14536608HCID 14536608, 화합물

생성물 1

HCID 19020542HCID 19020542, 화합물

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A solution of N-(3-methylbutyl)-10-[1-(1-pyrolidinyl)-2-propyl]-2-phenothiazinecarboxamide, L series (1.5 g), and methyl iodide (0.94 cc) in acetone (50 cc) is stirred for 4 days at a temperature in the region of 20° C. The light yellow solution obtained is concentrated to dryness under reduced pressure (30 mm Hg; 4 kPa) at 40° C., and the light cream-colored meringue-like residue is suspended with stirring for 10 minutes in diethyl ether (100 cc), drained, washed with diethyl ether (2×10 cc) and dried at 40° C. under reduced pressure (5 mm Hg, 0.7 kPa). 1-Methyl-1-{2-[2-(3-methylbutyl)carbamoyl-10-phenothiazinyl]propyl}-pyrrolidinium iodide, L series (1.55 g) is thereby obtained in the form of a light beige powder, m.p. about 125°-130° C., the NMR spectrum of which is identical to that of the product of Example 11.

후처리

  1. customThe light yellow solution obtained
  2. concentrationis concentrated to dryness under reduced pressure (30 mm Hg; 4 kPa) at 40° C.
  3. washwashed with diethyl ether (2×10 cc)
  4. customdried at 40° C. under reduced pressure (5 mm Hg, 0.7 kPa)

출처 및 근거

ORD 기록
ord-80d62a3c9a534c99adf6d1c33d23d2b2
출처 데이터셋
uspto-grants-1994_06
특허 번호
US05321026

반응 노트

불러오는 중…