3-Hydroxybenzyl alcohol → 2,7-Naphthalenediol

HRID 1109765

반응식

HRID 1109765 반응식
[Cl:1][CH2:2][C:3]1[S:4][C:5]2[CH:11]=[CH:10][C:9](C(F)(F)[F:13])=[CH:8][C:6]=2[N:7]=1.[OH:16][C:17]1[CH:18]=[C:19]([CH:22]=[CH:23][CH:24]=1)[CH2:20]O.[F:25]C(F)(F)[C:27]1[CH:28]=[CH:29][C:30]2[S:34][C:33]([CH2:35][O:36][C:37]3[CH:38]=[C:39]([CH:42]=[CH:43][CH:44]=3)[CH2:40]O)=[N:32][C:31]=2[CH:45]=1>>[Cl:1][CH2:2][C:3]1[S:4][C:5]2[CH:11]=[CH:10][C:9]([F:25])=[CH:8][C:6]=2[N:7]=1.[OH:16][C:17]1[CH:24]=[CH:23][C:22]2[C:19](=[CH:20][C:37]([OH:36])=[CH:44][CH:43]=2)[CH:18]=1.[F:13][C:27]1[CH:28]=[CH:29][C:30]2[S:34][C:33]([CH2:35][O:36][C:37]3[CH:44]=[CH:43][C:42]4[C:39](=[CH:40][C:17]([OH:16])=[CH:24][CH:23]=4)[CH:38]=3)=[N:32][C:31]=2[CH:45]=1.[Cl:1][CH2:2][C:3]1[CH:24]=[CH:23][C:5]2[C:6](=[CH:8][CH:9]=[C:10]([F:25])[CH:11]=2)[N:7]=1

참가 물질

7

반응물 3

HCID 1023-Hydroxybenzyl alcoholHCID 142042052-(Chloromethyl)-5-(trifluoromethyl)-1,3-benzothiazoleHCID 53867966HCID 53867966, 화합물

생성물 4

HCID 113972,7-NaphthalenediolHCID 112410072-(Chloromethyl)-6-fluoroquinolineHCID 14204210Benzothiazole, 2-(chloromethyl)-5-fluoro- (9CI)HCID 19019454HCID 19019454, 화합물

실험 절차

In a similar manner, starting with 2-chloromethyl-5-trifluoromethylbenzothiazole and 3-hydroxy benzyl alcohol and following this procedure, 3-(5-trifluoromethylbenzothiazol-2-ylmethoxy)benzyl alcohol was prepared, m.p. 117°-119° C., 2-chloromethyl-5-fluorobenzothiazole and 2,7-dihydroxynaphthalene gave 2-(5-fluorobenzothiazol-2-ylmethoxy)-7-hydroxynaphthalene, m.p. 218°-220° C., 2-chloromethyl-6-fluoroquinoline and m-resorcinol gave 3-(6-fluorocruinol-2-ylmethoxy)phenol, m.p. 146°-148° C. and 2-chloromethyl-5-fluorobenzothiazol and methyl 3-hydroxymandelate gave methyl 3-(5-fluorobenzothiazol-2-ylmethoxy)mandelate, m.p. 99°-101° C.

후처리

  1. customwas prepared

출처 및 근거

ORD 기록
ord-6b4668dbade64491afd029d8e78a6fd4
출처 데이터셋
uspto-grants-1994_06
특허 번호
US05322847

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