Hydrochloric Acid → 132523-84-3

HRID 1110035노트

반응식

HRID 1110035 반응식
[CH2:1]1[CH2:5][C:4]2([CH:10]3[CH2:11][N:12]([CH2:14][CH:15]4[CH2:17][CH2:16]4)[CH2:13][CH:6]2[CH2:7][N:8]([CH2:18][CH:19]2[CH2:21][CH2:20]2)[CH2:9]3)[CH2:3][CH2:2]1.[ClH:22]>C(O)(C)C>[CH2:1]1[CH2:5][C:4]2([CH:10]3[CH2:11][N:12]([CH2:14][CH:15]4[CH2:17][CH2:16]4)[CH2:13][CH:6]2[CH2:7][N:8]([CH2:18][CH:19]2[CH2:21][CH2:20]2)[CH2:9]3)[CH2:3][CH2:2]1.[ClH:22].[ClH:22]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 65825Tedisamil

생성물 1

HCID 11566690132523-84-3수율 80.2%

시약·촉매·용매 1

HCID 3776Isopropanol용매2회

실험 절차

2 g (=0.0069 mole) of tedisamil were dissolved in 5 ml of isopropanol. A solution of 0.53 g of hydrochloric acid in 5 ml of isopropanol was added with stirring to this solution. After the formation of salts, isopropanol was removed by distillation, and the tedisamil dihydrochloride which remained as a residue was recrystallized from acetone and dried at 60° C. in a vacuum drying oven. 2 g of tedisamil dihydrochloride were obtained. DSC gave a melting range with decomposition at 225.7 to 240.4° C. The base:acid ratio determined by titration was 1:2.0. Thermogravimetric analysis showed a 0.2% weight loss on drying.

후처리

  1. customAfter the formation of salts, isopropanol was removed by distillation
  2. customwas recrystallized from acetone
  3. customdried at 60° C. in a vacuum
  4. customdrying oven

출처 및 근거

ORD 기록
ord-83548e17acb04c64a79bd65c3471666e
출처 데이터셋
uspto-grants-1994_06
특허 번호
US05324732

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