Hydrochloric Acid → Spiro[indene-1,4'-piperidine] hydrochloride

HRID 1110038노트

반응식

HRID 1110038 반응식
C(OC([N:8]1[CH2:13][CH2:12][C:11]2([C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]=[CH:14]2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:22]>C(OCC)(=O)C>[ClH:22].[NH:8]1[CH2:13][CH2:12][C:11]2([C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]=[CH:14]2)[CH2:10][CH2:9]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 3653579Tert-butyl Spiro[indene-1,4'-piperidine]-1'-carboxylate

생성물 1

HCID 22509344Spiro[indene-1,4'-piperidine] hydrochloride수율 99%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

A solution of 1'-(tert-butyloxycarbonyl)spiro [indene-1,4'-piperidine] (3.0 g, 0.011 mol) in ethyl acetate (150 ml) was stirred at 0° C., and treated with hydrogen chloride for 30 minutes. The mixture was then evaporated to dryness, ethyl acetate (100 ml) was added, then removed in vacuo three times. The residue was stirred with anhydrous ether (200 ml), and the solid filtered off, to give spiro[indene-1,4'-piperidine] hydrochloride (2.3 g, 99%) as a pale yellow solid. The product was not purified further.

후처리

  1. customThe mixture was then evaporated to dryness, ethyl acetate (100 ml)
  2. additionwas added
  3. customremoved in vacuo three times
  4. filtrationthe solid filtered off

출처 및 근거

ORD 기록
ord-ad79964c21e64bd3b773478810b12fed
출처 데이터셋
uspto-grants-1994_06
특허 번호
US05324733

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