Methyl-3,5-didecoxybenzoate → Benzoic acid, 3,5-bis(decyloxy)-

HRID 1110212노트

반응식

HRID 1110212 반응식
C[O:2][C:3](=[O:32])[C:4]1[CH:9]=[C:8]([O:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])[CH:7]=[C:6]([O:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])[CH:5]=1>CO.[OH-].[Na+]>[CH2:22]([O:21][C:6]1[CH:5]=[C:4]([CH:9]=[C:8]([O:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])[CH:7]=1)[C:3]([OH:32])=[O:2])[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31]

참가 물질

4

반응물 1

HCID 10343663Methyl-3,5-didecoxybenzoate

생성물 1

HCID 10320747Benzoic acid, 3,5-bis(decyloxy)-수율 96.5%

시약·촉매·용매 2

HCID 887Methanol용매HCID 14798Sodium Hydroxide용매

실험 절차

A solution of 6.0 g (0.013 mol) of 3,5-bis(decyloxy)benzoic acid methyl ester in 300 ml of methanol and 40 ml of 1N sodium hydroxide was stirred at reflux for 3.5 hours. The reaction mixture was concentrated under reduced pressure and the residue was acidified with 6N HCl. The product was extracted with ethyl acetate and the dried extract was concentrated under reduced pressure to a yellow solid. Recrystallization from methanol-water gave 5.45 g (95% yield, mp 56°-58°) of 3,5-bis(decyloxy)benzoic acid.

후처리

  1. temperatureat reflux for 3.5 hours
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. extractionThe product was extracted with ethyl acetate
  4. extractionthe dried extract
  5. concentrationwas concentrated under reduced pressure to a yellow solid
  6. customRecrystallization from methanol-water

출처 및 근거

ORD 기록
ord-6a2cfd1a546e468f97d193d9d338ec7a
출처 데이터셋
uspto-grants-1994_06
특허 번호
US05324747

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