Triphenylphosphine → (4-Fluoro-3-phenoxyphenyl)methyltriphenylphosphonium chloride

HRID 1110411노트

반응식

HRID 1110411 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][Cl:9])=[CH:4][C:3]=1[O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[C:17]1([P:23]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>O1CCCC1>[Cl-:9].[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][P+:23]([C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[CH:4][C:3]=1[O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

4

반응물 2

HCID 11776TriphenylphosphineHCID 135636494-(Chloromethyl)-1-fluoro-2-phenoxybenzene

생성물 1

HCID 19754846(4-Fluoro-3-phenoxyphenyl)methyltriphenylphosphonium chloride수율 60.1%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 11.8 grams (0.05 mole) of 4-fluoro--3-phenoxyphenylmethyl chloride and 13.1 grams (0.05 mole) of triphenylphosphine in 150 mL of dry tetrahydrofuran was stirred for 72 hours. After this time the reaction mixture was concentrated under reduced pressure to a residual solid. The residue was stirred with diethyl ether and filtered to collect the solid. The solid was washed repeatedly with diethyl ether and dried yielding 15.0 grams of 4-fluoro-3-phenoxyphenylmethyltriphenylphosphonium chloride.

후처리

  1. concentrationAfter this time the reaction mixture was concentrated under reduced pressure to a residual solid
  2. filtrationfiltered
  3. customto collect the solid
  4. washThe solid was washed repeatedly with diethyl ether
  5. customdried

출처 및 근거

ORD 기록
ord-abab2ad225ab43298b07b82f686be21a
출처 데이터셋
uspto-grants-1990_12
특허 번호
US04975451

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