Sodium Hydroxide → (E)-5,5-bis(2-fluorophenyl)-2,4-pentadienoic acid

HRID 1110500노트

반응식

HRID 1110500 반응식
C([O:3][C:4](=[O:23])/[CH:5]=[CH:6]/[CH:7]=[C:8]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[F:22])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[F:15])C.[OH-].[Na+]>CO>[F:15][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[C:8]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[F:22])=[CH:7]/[CH:6]=[CH:5]/[C:4]([OH:23])=[O:3]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 86742562(E)-5,5-bis(2-fluorophenyl)-2,4-pentadienoic acid ethyl ester

생성물 1

HCID 14347238(E)-5,5-bis(2-fluorophenyl)-2,4-pentadienoic acid수율 93.7%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

As before. (E)-5.5-bis(2-fluorophenyl)-2,4-pentadienoic acid ethyl ester (1.7 g) in methanol (15 mL) was carried out using 4N sodium hydroxide (2.5 mL). After acidification, the product was extracted into dichloromethane (2×50 mL). The combined extracts were dried and evaporated and the residue crystallized from ether-hexane to provide 1.45 g of (E)-5,5-bis(2-fluorophenyl)-2,4-pentadienoic acid, mp 159°-160° C. Anal. Calculated for C17H12F2O2 : C, 71.32; H, 4.22; F, 13.27 Found: C, 71.09; H, 4.42; F, 13.26.

후처리

  1. extractionAfter acidification, the product was extracted into dichloromethane (2×50 mL)
  2. customThe combined extracts were dried
  3. customevaporated
  4. customthe residue crystallized from ether-hexane

출처 및 근거

ORD 기록
ord-2f52065b0a534eb1ac08ba88b5565de8
출처 데이터셋
uspto-grants-1990_12
특허 번호
US04975438

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