(E)-5,5-bis(4-chlorophenyl)-2,4-pentadienoic acid ethyl ester → (E)-5,5-bis(4-chlorophenyl)-2,4-pentadienoic acid

HRID 1110512노트

반응식

HRID 1110512 반응식
C([O:3][C:4](=[O:23])/[CH:5]=[CH:6]/[CH:7]=[C:8]([C:16]1[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=1)[C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=1)C>CO.[OH-].[Na+]>[Cl:15][C:12]1[CH:11]=[CH:10][C:9]([C:8]([C:16]2[CH:17]=[CH:18][C:19]([Cl:22])=[CH:20][CH:21]=2)=[CH:7]/[CH:6]=[CH:5]/[C:4]([OH:23])=[O:3])=[CH:14][CH:13]=1

참가 물질

4

반응물 1

HCID 14347256(E)-5,5-bis(4-chlorophenyl)-2,4-pentadienoic acid ethyl ester

생성물 1

HCID 14347245(E)-5,5-bis(4-chlorophenyl)-2,4-pentadienoic acid수율 95%

시약·촉매·용매 2

HCID 887Methanol용매HCID 14798Sodium Hydroxide용매

실험 절차

A mixture of (E)-5,5-bis(4-chlorophenyl)-2,4-pentadienoic acid ethyl ester (7.5 g) in methanol (30 mL) and 2N sodium hydroxide solution (15 mL) was heated at reflux for 30 minutes. The crude solid obtained from the usual work up, was crystallized from ether-hexane to yield 6.55 g of (E)-5,5-bis(4-chlorophenyl)-2,4-pentadienoic acid, mp 213°-215° C. Recrystallization of a portion from 2-propanol furnished the analytical sample, mp 214°-215° C. Anal. Calculated for C17H12Cl2O2 : C, 63.97; H, 3.79; Cl. 22.21 Found: C, 63.80; H, 3.90; Cl, 21.99.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 30 minutes
  3. customThe crude solid obtained from the usual work up,
  4. customwas crystallized from ether-hexane

출처 및 근거

ORD 기록
ord-56b8a04d912f4b879573f3012812d79f
출처 데이터셋
uspto-grants-1990_12
특허 번호
US04975438

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