Water → 2-p-Tolylbenzoxazole

HRID 1111088

반응식

HRID 1111088 반응식
[C:1]1([CH3:9])[CH:6]=[CH:5][C:4]([CH:7]=[O:8])=[CH:3][CH:2]=1.[NH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1O.O.C([O-])(=O)C.C([O-])(=O)C.C([O-])(=O)C.C([O-])(=O)C.[Pb+4]>C1(C)C=CC=CC=1>[CH3:9][C:1]1[CH:6]=[CH:5][C:4]([C:7]2[O:8][C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=3[N:10]=2)=[CH:3][CH:2]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 58012-AminophenolHCID 77254-MethylbenzaldehydeHCID 178418268HCID 178418268, 화합물

생성물 1

HCID 700392-p-Tolylbenzoxazole

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A solution of 120.2 g (1 mole) of 4-tolualdehyde and 109.1 g (1 mole) of 2-aminophenol in toluene is heated at reflux with azeotropic removal of water. After 20 hours at reflux, the reaction is cooled to room temperature, then 443.4 g (1 mole) of lead tetraacetate is added, and the mixture is stirred at room temperature for 20 hours. The solids are removed by filtration, and the filtrate is swirled with basic alumina. Removal of the solvent in vacuo affords the solid product which is then purified by recrystallization from ethanol.

후처리

  1. temperatureAfter 20 hours at reflux
  2. customThe solids are removed by filtration
  3. customRemoval of the solvent in vacuo
  4. customaffords the solid product which
  5. customis then purified by recrystallization from ethanol

출처 및 근거

ORD 기록
ord-7d9256f518ab4910a69dd2dc707f9056
출처 데이터셋
uspto-grants-1990_12
특허 번호
US04978476

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