홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Sodium Hydroxide → HCID 13645514, 화합물

HRID 1111122
노트
인쇄 미리보기

반응식

HRID 1111122 반응식
[CH3:1][C:2]1[N:3]([CH2:20][CH2:21][N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)[C:4]2[C:9]([C:10]=1[C:11](=[O:19])[C:12]1[CH:17]=[CH:16][C:15]([NH2:18])=[CH:14][CH:13]=1)=[CH:8][CH:7]=[CH:6][CH:5]=2.[N-:28]=[C:29]=[O:30].[Na+].[OH-].[Na+]>C(O)(=O)C.O>[CH3:1][C:2]1[N:3]([CH2:20][CH2:21][N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)[C:4]2[C:9]([C:10]=1[C:11](=[O:19])[C:12]1[CH:17]=[CH:16][C:15]([NH:18][C:29](=[O:30])[NH2:28])=[CH:14][CH:13]=1)=[CH:8][CH:7]=[CH:6][CH:5]=2
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 14798Sodium HydroxideHCID 11051568NaNCOHCID 13645496HCID 13645496, 화합물

생성물 1

HCID 13645514HCID 13645514, 화합물수율 48.4%

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 962Water용매3회

실험 절차

To a stirred suspension of 12.0 g. (0.03 mole) of 2-methyl-3-(4-aminobenzoyl)-1-[2-(4-morpholinyl)ethyl]- 1H-indole (Example 4B) in 15 ml of glacial acetic acid and 30 ml. of water was added a solution of 4.5 g. (0.06 mole) of sodium isocyanate in 30 ml of water. The mixture was stirred at room temperature for two hours, then diluted with water and made alkaline with 10% sodium hydroxide The solid which separated was collected and recrystallized from DMF to give 5.9 g (48%) of 2-methyl3-(4-carbamylaminobenzoyl)-1-[2-(4-morpholinyl)ethyl]-1H-indole, m p. 192°-202° C.

후처리

  1. additionTo a stirred suspension of 12.0 g
  2. customseparated
  3. customwas collected
  4. customrecrystallized from DMF

출처 및 근거

ORD 기록
ord-4517a4a6dcbf445e99b6a379e4c267aa
출처 데이터셋
uspto-grants-1990_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04978664

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트