Ammonium formate → 2,2-Dimethyl-1,3-dioxan-5-amine

HRID 1111256노트

반응식

HRID 1111256 반응식
[CH3:1][C:2]1([CH3:11])[O:7][CH2:6][CH:5]([N+:8]([O-])=O)[CH2:4][O:3]1.C([O-])=O.[NH4+]>CO.[Pd]>[CH3:1][C:2]1([CH3:11])[O:7][CH2:6][CH:5]([NH2:8])[CH2:4][O:3]1

참가 물질

5

반응물 2

HCID 2723923Ammonium formateHCID 108774282,2-Dimethyl-5-nitro-1,3-dioxane

생성물 1

HCID 117686082,2-Dimethyl-1,3-dioxan-5-amine수율 70.3%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

220 mg 5% Pd/C was added to a solution of 500 mg 2,2-dimethyl-5-nitro-1,3-dioxane (3.1 mmoles) in 30 ml methanol. Ammonium formate (985 mg, 15.6 mmoles) was then added, and the mixture was refluxed for three hours. The reaction solution was then filtered, and the filtrate concentrated in vacuo to yield 286 mg 2,2-dimethyl-5-amino-1,3-dioxane (70% yield).

후처리

  1. temperaturethe mixture was refluxed for three hours
  2. filtrationThe reaction solution was then filtered
  3. concentrationthe filtrate concentrated in vacuo

출처 및 근거

ORD 기록
ord-42e6471954b34b13ba19fe924c582782
출처 데이터셋
uspto-grants-1990_12
특허 번호
US04978793

반응 노트

불러오는 중…