Acetyl chloride → 1-(1,1,2,3,3-Pentamethyl-2,3-dihydro-1H-inden-5-yl)ethan-1-one

HRID 1111546

반응식

HRID 1111546 반응식
[CH3:1][C:2]1([CH3:14])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH3:12])([CH3:11])[CH:3]1[CH3:13].[C:15](Cl)(=[O:17])[CH3:16].[Cl-].[Al+3].[Cl-].[Cl-]>>[C:15]([C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[C:4]([CH3:12])([CH3:11])[CH:3]([CH3:13])[C:2]2([CH3:14])[CH3:1])(=[O:17])[CH3:16]

참가 물질

4

반응물 3

HCID 6367Acetyl chlorideHCID 145491,1,2,3,3-PentamethylindanHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 1073331-(1,1,2,3,3-Pentamethyl-2,3-dihydro-1H-inden-5-yl)ethan-1-one

실험 절차

To a mixture, stirred at ambient temperature in the absence of the humidity of the air, of 25 g of 1,1,2,3,3-pentamethyl indane and 13 cm3 of acetyl chloride, there are added, in small portions, 23 g of aluminum chloride in a manner such that the temperature does not exceed 40° C. Stirring is maintained for 2 hours after the end of the addition and the reaction mixture is left overnight. The next day, it is poured into 200 cm3 of ice water and then extracted three times with 150 cm3 of dichloromethane. The organic phases are combined, washed with sodium bicarbonate and then with water and dried on magnesium sulfate. The solvent is removed by evaporation under a vacuum and 31 g of 5-acetyl-1,1,2,3,3-pentamethyl indane in liquid form which is directly used for the following reactions are obtained.

후처리

  1. customdoes not exceed 40° C
  2. temperatureis maintained for 2 hours
  3. additionafter the end of the addition
  4. extractionextracted three times with 150 cm3 of dichloromethane
  5. washwashed with sodium bicarbonate
  6. dry with materialwith water and dried on magnesium sulfate
  7. customThe solvent is removed by evaporation under a vacuum and 31 g of 5-acetyl-1,1,2,3,3-pentamethyl indane in liquid form which
  8. customare obtained

출처 및 근거

ORD 기록
ord-7f9cbff27c134d79bfc4decf39a258d2
출처 데이터셋
uspto-grants-1990_12
특허 번호
US04980509

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