Dimethyl Sulfoxide → 2-(4-Methyl-phenoxy)-5-methyl-phenylacetonitrile

HRID 1111795노트

반응식

HRID 1111795 반응식
Cl[CH2:2][C:3]1[CH:4]=[C:5]([CH3:17])[CH:6]=[CH:7][C:8]=1[O:9][C:10]1[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][CH:11]=1.CS(C)=O.[C-:22]#[N:23].[Na+]>O>[CH3:16][C:13]1[CH:14]=[CH:15][C:10]([O:9][C:8]2[CH:7]=[CH:6][C:5]([CH3:17])=[CH:4][C:3]=2[CH2:2][C:22]#[N:23])=[CH:11][CH:12]=1

참가 물질

5

반응물 3

HCID 679Dimethyl Sulfoxide2회HCID 8929Sodium CyanideHCID 227679253-Chloromethyl-4-(4-methyl-phenoxy)-toluene

생성물 1

HCID 543008532-(4-Methyl-phenoxy)-5-methyl-phenylacetonitrile

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
36 °C

실험 절차

A solution of 108 g. of 3-chloromethyl-4-(4-methyl-phenoxy)-toluene in 70 ml. of dimethylsulfoxide is added dropwise at 20°-25° C. to a suspension of 23 g. of sodium cyanide in 35 ml. of dimethylsulfoxide. The mixture is subsequently stirred for 4 hours at 36° C., then diluted with 1 liter of water and extracted three times with benzene. The benzene extracts are washed three times with water, then dried over sodium sulfate and evaporated in vacuo, and there is obtained crude 2-(4-methyl-phenoxy)-5-methyl-phenylacetonitrile as a brown oil.

후처리

  1. extractionextracted three times with benzene
  2. washThe benzene extracts are washed three times with water
  3. dry with materialdried over sodium sulfate
  4. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-30d070ebd3414a89b0e418f5fea9bb16
출처 데이터셋
uspto-grants-1978_10
특허 번호
US04118572

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