Phosphorus oxychloride → Ethyl 5-Hydroxy-4-Methyl-7-(3-Methyl-2-Octyl)-Coumarin-3-Propionate

HRID 1112114

반응식

HRID 1112114 반응식
[CH3:1][CH:2]([CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[CH:3]([C:5]1[CH:6]=[C:7]([OH:12])[CH:8]=[C:9]([CH:11]=1)[OH:10])[CH3:4].[C:18]([CH:21]([CH2:27][CH2:28][C:29]([O:31][CH2:32][CH3:33])=[O:30])[C:22](OCC)=[O:23])(=O)[CH3:19].P(Cl)(Cl)(Cl)=O>>[OH:10][C:9]1[CH:11]=[C:5]([CH:3]([CH:2]([CH3:1])[CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[CH3:4])[CH:6]=[C:7]2[C:8]=1[C:18]([CH3:19])=[C:21]([CH2:27][CH2:28][C:29]([O:31][CH2:32][CH3:33])=[O:30])[C:22](=[O:23])[O:12]2

참가 물질

4

반응물 3

HCID 24813Phosphorus oxychlorideHCID 73915Diethyl 2-acetylglutarateHCID 2581765-(3-Methyloctan-2-yl)benzene-1,3-diol

생성물 1

HCID 22765004Ethyl 5-Hydroxy-4-Methyl-7-(3-Methyl-2-Octyl)-Coumarin-3-Propionate

실험 절차

A mixture of 262 g. (1.109 mole) of 5-(3-methyl-2-octyl)resorcinol, 283 g. (1.23 mole) of diethyl α-acetylglutarate, and 170 g. (1.11 mole) of phosphorus oxychloride protected from atmospheric moisture is stirred at room temperature for 12 days. The mixture is taken up in benzene-ether and the solution is washed several times with water, aqueous sodium bicarbonate, water and dried over anhydrous magnesium sulfate. After removal of the solvent, 441 g. of an oil is obtained, which solidifies on standing.

후처리

  1. additionA mixture of 262 g
  2. washthe solution is washed several times with water, aqueous sodium bicarbonate, water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customAfter removal of the solvent, 441 g
  5. customof an oil is obtained

출처 및 근거

ORD 기록
ord-5cd16492be3548a8a610fa0336f0d8bd
출처 데이터셋
uspto-grants-1978_10
특허 번호
US04120873

연결된 노트

불러오는 중…