Benzylamine → 1-Benzyl-3-phenylurea

HRID 1112332

반응식

HRID 1112332 반응식
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:9]1([NH:15][C:16](OC2C(O)=C(C3C=CC=CC=3)S(=O)(=O)C=2C2C=CC=CC=2)=[O:17])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>C(OCC)(=O)C>[CH2:1]([NH:8][C:16]([NH:15][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:17])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 7504BenzylamineHCID 227636553-(Phenylcarbamyloxy)-4-hydroxy-2,5-diphenylthiophene-1,1-dioxide

생성물 1

HCID 2803631-Benzyl-3-phenylurea

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

540 mg of benzylamine are added to 2.1 g of 3-(N-phenylcarbamyloxy)-4-hydroxy-2,5-diphenylthiophene-1,1-dioxide in 20 ml of ethyl acetate. The solution is boiled under reflux for 1 hour and then washed three times with 25 ml of concentrated aqueous NaHCO3 solution and three times with 20% strength aqueous citric acid solution. The wash liquors are extracted with ethyl acetate and the combined organic phases are dried over magnesium sulfate. After evaporating the filtrate, the crystalline residue is recrystallized from dilute ethanol.

후처리

  1. temperatureunder reflux for 1 hour
  2. washwashed three times with 25 ml of concentrated aqueous NaHCO3 solution and three times with 20% strength aqueous citric acid solution
  3. extractionThe wash liquors are extracted with ethyl acetate
  4. dry with materialthe combined organic phases are dried over magnesium sulfate
  5. customAfter evaporating the filtrate
  6. customthe crystalline residue is recrystallized from dilute ethanol

출처 및 근거

ORD 기록
ord-195cfb6f7ac3451089078aa7bd2aced2
출처 데이터셋
uspto-grants-1978_10
특허 번호
US04122090

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