Ethyl Acetate → cis-3-Azido-4-oxo-2-azetidinylmethyl bromide

HRID 1112344노트

반응식

HRID 1112344 반응식
S(C1C=CC(C)=CC=1)(O[CH2:5][C@H:6]1[C@@H:9]([N:10]=[N+:11]=[N-:12])[C:8](=[O:13])[NH:7]1)(=O)=O.[Li+].[Br-:22].C(OCC)(=O)C>CN(C)C=O>[N:10]([C@H:9]1[C:8](=[O:13])[NH:7][C@H:6]1[CH2:5][Br:22])=[N+:11]=[N-:12]

참가 물질

5

반응물 3

HCID 8857Ethyl AcetateHCID 82050Lithium BromideHCID 86734335HCID 86734335, 화합물

생성물 1

HCID 86736078cis-3-Azido-4-oxo-2-azetidinylmethyl bromide

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A degassed solution of cis-3-azido-4-oxo-2-azetidinylmethyl tosylate (0.41 g, 1.4 mmol) in dimethylformamide (5 ml) was heated to 90° with LiBr (0.43 g, 5 mmol) for 4 hours. The reaction was poured into ethyl acetate and washed copiously with water. The dried solution was evaporated to give the title compound.

후처리

  1. washwashed copiously with water
  2. customThe dried solution was evaporated

출처 및 근거

ORD 기록
ord-7f9dc7402b6f40cfba065dd4816442d6
출처 데이터셋
uspto-grants-1978_10
특허 번호
US04122086

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