(4-Chlorophenoxy)acetic acid → Apovincamine p-chlorophenoxyacetate

HRID 1112370

반응식

HRID 1112370 반응식
[CH3:1][CH2:2][C@:3]12[CH:19]=[C:18]([C:20]([O:22][CH3:23])=[O:21])[N:17]3[C:9]4=[C:10]([CH2:24][CH2:25][N:7]([C@@H:8]14)[CH2:6][CH2:5][CH2:4]2)[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=13.[Cl:26][C:27]1[CH:37]=[CH:36][C:30]([O:31][CH2:32][C:33]([OH:35])=[O:34])=[CH:29][CH:28]=1>O>[CH3:1][CH2:2][C@:3]12[CH:19]=[C:18]([C:20]([O:22][CH3:23])=[O:21])[N:17]3[C:9]4=[C:10]([CH2:24][CH2:25][N:7]([C@@H:8]14)[CH2:6][CH2:5][CH2:4]2)[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=13.[Cl:26][C:27]1[CH:28]=[CH:29][C:30]([O:31][CH2:32][C:33]([O-:35])=[O:34])=[CH:36][CH:37]=1

참가 물질

4

반응물 2

HCID 26229(4-Chlorophenoxy)acetic acidHCID 71204Apovincamine2회

생성물 1

HCID 86736093Apovincamine p-chlorophenoxyacetate수율 76.9%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

4 g of the salt are prepared, according to the method of the example 19.a, starting from 3.36 g of apovincamine and 1.86 g of p-chlorophenoxyacetic acid. The melting point of the salt is about 120° C. and it is insoluble in water; the content of apovincamine is 64%.

후처리

  1. customis about 120° C.

출처 및 근거

ORD 기록
ord-a954cd595ef546c78021c8ee5f67fc0a
출처 데이터셋
uspto-grants-1978_10
특허 번호
US04122179

연결된 노트

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