Sodium borohydride → N-[[2-[3-(4-Morpholinyl)propoxy]phenyl]methyl]benzeneethanamine

HRID 1112442노트

반응식

HRID 1112442 반응식
[N:1]1([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH:17]=[N:18][CH2:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[BH4-].[Na+]>CO>[N:1]1([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH2:17][NH:18][CH2:19][CH2:20][C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH2:2][CH2:3][O:4][CH2:5][CH2:6]1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 20394050N-[[2-[3-(4-Morpholinyl)propoxy]phenyl]methylene]benzeneethanamine

생성물 1

HCID 21322756N-[[2-[3-(4-Morpholinyl)propoxy]phenyl]methyl]benzeneethanamine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

N-[[2-[3-(4-Morpholinyl)propoxy]phenyl]methylene]-benzeneethanamine (17g) is reduced with 5.4g of sodium borohydride in 85 ml of methanol following the procedure described in Example 1B to yield 12.8g of product as an oil, boiling point 219°-223° C at 0.1-0.2 mm of Hg.

출처 및 근거

ORD 기록
ord-5339cb7e8d0e41b4b42a02452c167729
출처 데이터셋
uspto-grants-1978_10
특허 번호
US04122255

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