Hydrochloric Acid → trans-Aconitic acid

HRID 1112609

반응식

HRID 1112609 반응식
[OH-].[Sr+2].[OH-].Cl.[C:5]([OH:17])(=[O:16])[CH:6]([CH:8]([CH2:12][C:13]([OH:15])=[O:14])[C:9]([OH:11])=[O:10])O>O>[CH2:12]([C:13]([OH:15])=[O:14])/[C:8](/[C:9]([OH:11])=[O:10])=[CH:6]\[C:5]([OH:17])=[O:16]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 1198Isocitric AcidHCID 87672Strontium hydroxide2회

생성물 1

HCID 444212trans-Aconitic acid수율 60.5%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Thirty one grams (0.1 mole) of the product prepared in Example I-B is mixed with 300 mls water. 79 grams of strontium hydroxide (0.65 mole) is added slowly at 65°-70° C. while maintaining the pH at 10-10.5. The mixture is stirred for an additional three hours after the addition of the strontium hydroxide. The solution is cooled and 180 grams of 10% hydrochloric acid is added slowly to a pH of 1.3. The acidified solution is next evaporated to dryness in vacuo. The residue is extracted with acetone and the acetone extract is filtered and evaporated to dryness. There is thus obtained 23 g of residue containing 45.7% (60.5% yield) trans-aconitic acid and 10.7% of a mixture of the lactones of isocitric acid and alloisocitric acid.

후처리

  1. temperaturewhile maintaining the pH at 10-10.5
  2. temperatureThe solution is cooled
  3. customnext evaporated to dryness in vacuo
  4. extractionThe residue is extracted with acetone
  5. extractionthe acetone extract
  6. filtrationis filtered
  7. customevaporated to dryness

출처 및 근거

ORD 기록
ord-f5d451fa46ce4a43b84a2ab3e395362a
출처 데이터셋
uspto-grants-1978_10
특허 번호
US04123459

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