Dimethylformamide → 1,3-Benzothiazole-6-sulfonyl chloride

HRID 11251

반응식

HRID 11251 반응식
S(Cl)([Cl:3])=O.[S:5]1[C:9]2[CH:10]=[C:11]([S:14]([OH:17])(=O)=[O:15])[CH:12]=[CH:13][C:8]=2[N:7]=[CH:6]1.CN(C)C=O>ClC(Cl)C>[Cl:3][S:14]([C:11]1[CH:12]=[CH:13][C:8]2[N:7]=[CH:6][S:5][C:9]=2[CH:10]=1)(=[O:17])=[O:15]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 143978241,3-Benzothiazole-6-sulfonic acid

생성물 1

HCID 27951701,3-Benzothiazole-6-sulfonyl chloride

시약·촉매·용매 1

HCID 63651,1-Dichloroethane용매

실험 절차

Thionyl chloride (4 mL) was added to a suspension of the benzothiazole-6-sulfonic acid (0.60 g, 2.79 mmol) in dichloroethane (15 mL) and the reaction mixture was heated at reflux and dimethylformamide (5 mL) was added to the reaction mixture to yield a clear solution. After 1.5 hr. at reflux, the solvent was removed in vacuo and excess HCl and thionyl chloride was chased by evaporation with dichloroethane.

후처리

  1. temperaturethe reaction mixture was heated
  2. temperatureat reflux
  3. customto yield a clear solution
  4. temperatureat reflux
  5. customthe solvent was removed in vacuo and excess HCl and thionyl chloride
  6. customwas chased by evaporation with dichloroethane

출처 및 근거

ORD 기록
ord-65102f31262e4021b5784cb373f3c5c1
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07098202B2

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