Pyridine → 2-[5-(4-n-Butoxybenzenesulfonylamino)-2-ethoxyphenyl]-5-methyl-7-cyclopentyl-3H-imidazo-[5,1-f][1,2,4]-triazin-4-one

HRID 11271

반응식

HRID 11271 반응식
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:24][CH2:25][CH3:26])=[C:6]([C:8]2[NH:13][C:12](=[O:14])[C:11]3=[C:15]([CH3:23])[N:16]=[C:17]([CH:18]4[CH2:22][CH2:21][CH2:20][CH2:19]4)[N:10]3[N:9]=2)[CH:7]=1.[CH2:27]([O:31][C:32]1[CH:37]=[CH:36][C:35]([S:38](Cl)(=[O:40])=[O:39])=[CH:34][CH:33]=1)[CH2:28][CH2:29][CH3:30].N1C=CC=CC=1>O1CCCC1>[CH2:27]([O:31][C:32]1[CH:37]=[CH:36][C:35]([S:38]([NH:1][C:2]2[CH:3]=[CH:4][C:5]([O:24][CH2:25][CH3:26])=[C:6]([C:8]3[NH:13][C:12](=[O:14])[C:11]4=[C:15]([CH3:23])[N:16]=[C:17]([CH:18]5[CH2:22][CH2:21][CH2:20][CH2:19]5)[N:10]4[N:9]=3)[CH:7]=2)(=[O:40])=[O:39])=[CH:34][CH:33]=1)[CH2:28][CH2:29][CH3:30]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 5179904-Butoxybenzenesulfonyl ChlorideHCID 1356049412-(5-Amino-2-ethoxyphenyl)-5-methyl-7-cyclopentyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one

생성물 1

HCID 1356049382-[5-(4-n-Butoxybenzenesulfonylamino)-2-ethoxyphenyl]-5-methyl-7-cyclopentyl-3H-imidazo-[5,1-f][1,2,4]-triazin-4-one

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

150 mg (0.424 mmol) of the compound from example 42A are reacted with 186 mg (0.747 mmol) of 4-(n-butoxy)-benzenesulfonyl chloride and 0.34 g (4.30 mmol) of pyridine in 6 ml of tetrahydrofuran.

출처 및 근거

ORD 기록
ord-19738cf49f484ac1b29bcf3080bba171
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07098207B2

연결된 노트

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