Tetrahydrofuran → tert-butyl 4-[4-[[2-[5-amino-1-[(2-methylpropan-2-yl)oxy]-1,5-dioxopentan-2-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]phenyl]piperidine-1-carboxylate

HRID 1128237

반응식

HRID 1128237 반응식
[CH2:79]1[O:80][CH2:81][CH2:82][CH2:83]1.[NH2:1][C:2]([CH2:3][CH2:4][CH:5]([C:6](=[O:7])[O:8][C:9]([CH3:10])([CH3:11])[CH3:12])[N:13]1[C:14](=[O:23])[c:15]2[cH:16][cH:17][cH:18][c:19]([OH:22])[c:20]2[CH2:21]1)=[O:24].[O:44]=[C:45]([O:46][CH:47]([CH3:48])[CH3:49])[N:50]=[N:51][C:52]([O:53][CH:54]([CH3:55])[CH3:56])=[O:57].[OH:58][CH2:59][c:60]1[cH:61][cH:62][c:63]([CH:66]2[CH2:67][CH2:68][N:69]([C:72](=[O:73])[O:74][C:75]([CH3:76])([CH3:77])[CH3:78])[CH2:70][CH2:71]2)[cH:64][cH:65]1.[c:25]1([P:26]([c:27]2[cH:28][cH:29][cH:30][cH:31][cH:32]2)[c:33]2[cH:34][cH:35][cH:36][cH:37][cH:38]2)[cH:39][cH:40][cH:41][cH:42][cH:43]1>>[NH2:1][C:2]([CH2:3][CH2:4][CH:5]([C:6](=[O:7])[O:8][C:9]([CH3:10])([CH3:11])[CH3:12])[N:13]1[C:14](=[O:23])[c:15]2[cH:16][cH:17][cH:18][c:19]([O:22][CH2:59][c:60]3[cH:61][cH:62][c:63]([CH:66]4[CH2:67][CH2:68][N:69]([C:72](=[O:73])[O:74][C:75]([CH3:76])([CH3:77])[CH3:78])[CH2:70][CH2:71]4)[cH:64][cH:65]3)[c:20]2[CH2:21]1)=[O:24]

참가 물질

6

반응물 5

HCID 8028TetrahydrofuranHCID 11776TriphenylphosphineHCID 75555Diisopropyl diazene-1,2-dicarboxylateHCID 220770564-(4-Hydroxymethylphenyl)piperidine-1-carboxylic acid t-butyl esterHCID 67334268tert-butyl 5-amino-2-(7-hydroxy-3-oxo-1H-isoindol-2-yl)-5-oxopentanoate

생성물 1

HCID 67334337tert-butyl 4-[4-[[2-[5-amino-1-[(2-methylpropan-2-yl)oxy]-1,5-dioxopentan-2-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]phenyl]piperidine-1-carboxylate

출처 및 근거

ORD 기록
ord-74a056ba092546e4b3c5451e97d9af1c
출처 데이터셋
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

연결된 노트

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