Cyclohexylamine → N-cyclohexyl-3-nitropyridin-2-amine
반응식
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH:11]1([NH2:17])[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH:11]1([NH:17][C:2]2[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=2)[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1참가 물질
5
실험 절차
A mixture composed of 0.1 mol (15.85 g) of 2-chloro-3-nitropyridine and 0.1 mol (11.50 ml) of cyclohexylamine is heated at 120° C. for 4 hours in 250 ml of DMF in the presence of potassium carbonate (13.81 g). The solution is then extracted with 200 ml of ether and the organic phase is washed three times with water. After drying over magnesium sulphate, the ether is evaporated off.
후처리
- extractionThe solution is then extracted with 200 ml of ether
- washthe organic phase is washed three times with water
- dry with materialAfter drying over magnesium sulphate
- customthe ether is evaporated off
출처 및 근거
- ORD 기록
- ord-bb30373df9eb45569b1a021302201d7c
- 출처 데이터셋
- uspto-grants-2006_08
- 특허 번호
- US07098220B2
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