Cyclohexylamine → N-cyclohexyl-3-nitropyridin-2-amine

HRID 11285

반응식

HRID 11285 반응식
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH:11]1([NH2:17])[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH:11]1([NH:17][C:2]2[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=2)[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1

참가 물질

5

반응물 3

HCID 7965CyclohexylamineHCID 11430Potassium CarbonateHCID 796132-Chloro-3-nitropyridine

생성물 1

HCID 535050N-cyclohexyl-3-nitropyridin-2-amine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture composed of 0.1 mol (15.85 g) of 2-chloro-3-nitropyridine and 0.1 mol (11.50 ml) of cyclohexylamine is heated at 120° C. for 4 hours in 250 ml of DMF in the presence of potassium carbonate (13.81 g). The solution is then extracted with 200 ml of ether and the organic phase is washed three times with water. After drying over magnesium sulphate, the ether is evaporated off.

후처리

  1. extractionThe solution is then extracted with 200 ml of ether
  2. washthe organic phase is washed three times with water
  3. dry with materialAfter drying over magnesium sulphate
  4. customthe ether is evaporated off

출처 및 근거

ORD 기록
ord-bb30373df9eb45569b1a021302201d7c
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07098220B2

연결된 노트

불러오는 중…