Potassium Hydroxide → 2-(Benzylsulfanyl)benzoic acid

HRID 11309

반응식

HRID 11309 반응식
C([O:8][C:9](=[O:24])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[S:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)C1C=CC=CC=1.[OH-].[Na+].[OH-].[K+]>>[CH2:17]([S:16][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=1[C:9]([OH:24])=[O:8])[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

참가 물질

4

반응물 3

HCID 14797Potassium HydroxideHCID 14798Sodium HydroxideHCID 802018Benzyl 2-(benzylsulfanyl)benzoate

생성물 1

HCID 2641822-(Benzylsulfanyl)benzoic acid

실험 절차

To a suspension of 2-benzylsulfanyl benzoic acid benzyl ester 2 (113 mg, 0.34 mmol) was added 1.6 mL of 1N NaOH. KOH (1 pellet) was added and the reaction was continued overnight. The acetone was removed and a small amount of water was added. The aqueous solution was washed with CH2Cl2(3). The aqueous phase was acidified until pH of 2–3 was reached then extracted with CH2Cl2(3X), dried with MgSO4 and filtered and concentrated to give a white solid.

후처리

  1. customThe acetone was removed
  2. additiona small amount of water was added
  3. washThe aqueous solution was washed with CH2Cl2(3)
  4. extractionwas reached then extracted with CH2Cl2(3X)
  5. dry with materialdried with MgSO4
  6. filtrationfiltered
  7. concentrationconcentrated
  8. customto give a white solid

출처 및 근거

ORD 기록
ord-5efd89b5050f46a987a88ade1df59f7b
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07098223B2

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